Andarine S4: A Comprehensive Guide to the Uses, Benefits, and Side Effects

Health & Fitness by  Abdul Aziz Mondal 10 April 2021 Last Updated Date: 28 June 2023

Andarine S4

Andarine S4 is a very useful SARM that can help with a variety of conditions but also has use for general health and muscle building.

In essence, Andarine was first developed with the idea of treating osteoporosis and muscle wasting. However, due to discontinuation for the development of another SARM, Andarine has lost its audience until picked up by the bodybuilding community.

In this article, we will cover everything you need to know about the benefits of Andarine, as well as the side effects. By considering the good and the bad, you will be able to decide if this SARM is right for you.

Whenever you’re ready to learn about the bone-building and muscle-growing power of S4, keep reading.

What Is Andarine S4?

Primarily known as Andarine, S4 is a SARM created to treat muscle atrophy and osteoporosis. Selective androgen receptor modulators are chemical compounds that bind to the androgens, which is the primary locale for testosterone production.

In the nascent years of Andarine, it was considered to be the greatest SARM because of the oral bioavailability and the bone-muscle building effects.

There have been some trials with success in human trials, but it’s not substantial to make any real judgments. Development of Andarine was slowed down and abrupted because of its counterpart Ostarine S-22.

This most likely occurred because of the safety profile that Andarine had. There was potential for eye-sight side effects, among many other side effects that are less than favorable. However this potential is little to none now and this is largely attributed to the arrival of Selective Androgen Receptor Modulators (*SARMs*). This is why SARMs are often praised as a safer alternative to traditional anabolic steroids.

Because SARMs are selective by their very nature, their binding to hormones is targeted, and results can be expected. These supplements do not latch on to every enzyme, tissue, or hormone.

Many people suffer from muscle atrophy, especially individuals of older age and those who have a genetic predisposition to such outcomes. In addition to curing and regulating muscle wasting, Andarine also strengthens the bones.

It has also been widely tested as a treatment option for benign prostatic hypertrophy.

What Are SARMs?

SARMs are somewhat like anabolic steroids. They are certainly not the same thing, however. Both work by having the compound bind with the androgen receptors, which activates changes in your hormone secretion and DNA, resulting in various bodily changes.

Steroids are quite a wide-scale tool, they also have an impact on other parts of the body, which often leads to issues like acne, hair loss, and prostate hypertrophy. On the other hand, SARMs are selective in their tissue, they target the muscles exclusively without setting off a reaction with unexpected side effects.

Not to mention, SARMs are consumed in a pill form, unlike steroids that are injected. The primary downside to SARMs is that no SARM has ever been approved for human consumption.

Read more: SARMs Drugs vs. Steroids: Getting Those Gains Right

The Method Of Action

Because Andarine has an affinity for androgen receptors, it will mimic the effects of natural testosterone production. But its effects will be most noticeable in the bones and muscle, not the reproductive organs. This is why SARMs in general are known to have fewer side effects than traditional steroids.

The problem persists that many bodybuilders will take this theory as proof to avoid dealing with estrogen or testosterone suppression. But this is not the case for SARMs. Because there is no true understanding behind the selectivity of SARMs, it’s best to be cautious when considering their use.

The method of action is only theoretical and requires a degree of a substantial clinical trial to occur for real proof to appear for all audiences who might consider using SARMs.

The Benefits Of Use

The primary benefit and popular effect is the ability to build muscle. Even though this supplement is not intended for muscle mass growth, it’s quite easy for individuals to gain several pounds on their cycles.

Andarine is best for getting lean muscle because it also helps you lose fat simultaneously, it’s not great for bulking. Not only does Andarine quicken fat loss, but it makes muscle mass easier to retain on a regular diet. When using Andarine, you will lose fat even with a surplus in calories.

Most people who use Andarine can lose several percent of body fat in their cycle. Nonetheless, these results are dependent on your exercise regime and the types/quantity of foods eaten.

S4 is also great for general recovery. The average recovery time for people is about 3 days. With the use of Andarine, this number can go down to a single day if there is such capability in your body. This means that you can get back to your workouts faster, which will result in quicker strength and muscle gains.

Andarine is most useful for body composition. Because you will lose fat and gain muscle, you will make your body comp much better. Those who are skinny fat will see the best improvements with Andarine.

And finally, Andarine does improve your strength. The gains are not severely outrageous like on RAD140 or LDG4033, but they are better than Ostarine. The best part is that you get to keep your strength gains if you continue to train hard after your cycles.

Additional Information

S4 was created by Kaken Pharmaceuticals, which is a Japanese company. The effects of Andarine were observed on muscle wasting. However, Andarine has since then transformed significantly.

The side effects that were once present are mostly gone in the newer versions. It’s certainly not the most potent of SARMs, but it’s still quite popular. Most SARMs have some side effects, Andarine makes adaptation much safer, resulting in fewer side effects.

Andarine is capable of healing fractures quicker than usual, regulating the pain of brittle bones, improving bone density. Hence, Andarine is great for the skeletal health of the users.

The substance helps with tissue regeneration. It can help individuals put on weight if they are having trouble doing so. In any case, the purpose is not to gain muscle, but to arrest the atrophy of it.

Sustainability is crucial with Andarine. The concept of gaining lots of muscle is futile because these gains would be lost after the cycle. But with slow and steady progression with the supported continuation of exercise after cycle cessation, the progress will be retained.

Safety Concerns

Andarine is not an approved substance, and the effects are mostly unknown to the body. SARMs are selective in nature, but this is yet to be proven with concrete evidence. People often perceive SARMs to be safer because of the misunderstanding of science.

The SARMs selectivity theory, which “results in fewer side effects” does not have any true proof behind it. Andarine has never been through significant clinical trials either. In fact, SARMs can end up being more dangerous than other substances, but this is also unproven.

Follicle-stimulating hormone and luteinizing hormone promote reproductive health in men and women. Their suppression results in teh suppression of testosterone and estrogen.

In a study with castrated rats, Andarine suppressed both where the hormones were above normal due to castration. It did not affect healthy normal rats. In any case, there is too much unknown about how Andarine could suppress hormone production.

The most common side effects with Andarine are visual problems, such as night vision weakness and a yellow tint. The effects disappear after the substance has been stopped. The larger the dose, the more likely the side effects will happen.

The effects and safety of Andarine have not been substantially examined in humans, and if this data does exist, it is not publicly available. Andarine can be bought online, but before you do so, you must speak to a medical specialist to consider any implications.

Andarine Side Effects

The side effects of Andarine are similar to MK-2866. This means it has fewer side effects than most SARMs and its counterpart Ostarine. The reason behind this is the potency of the effects on receptors.

Because of the lower potency, people often try to opt in for larger doses. The problem with that is that larger doses are directly related to greater side effects. A cautionary approach to such compounds is the best way to mitigate the side effects of trying substances that one has not researched.

No matter which method of consumption you have chosen for your S4, you should steadily and slowly assess your dosage over the course of 8 weeks. Within this time, you will examine changes in your body. Muscle wasting will arrest and you will experience a fat loss with muscle gain.

The bones will feel stronger and if you have skeletal pain with a reduced range of motion, you will experience severe relief from these symptoms. However, you should not let your guard down, because there is the potential for hormone side effects.

If you opt for large doses, you might see hormone suppression. Changes in hormone secretion and/or imbalances are not something to wish for. You should never go beyond 100mg of Andarine per day.

Take a moderate dosage and break it down for several uses per day. The substance has a short half-life, which means it’s best to take less more often than more less often.

Andarine Dosing

For this drug, there is no approved safe dosage because it has not been examined by a regulatory body. In animal studies, Andarine had a half-life of about 200 minutes.

To better understand the available data on dosages, we have collected the following information to attempt to warn users about the inappropriate usage of this substance.

According to anecdotal reports, the most common dosage is about 50 mg per day, divided into 3 uses when taken with meals. Some individuals opt for lower dosages, 25 mg is the lowest common number. Andarine must be cycled.

The drug is unapproved, meaning the identity and quantity of the product can be under great speculation. Upon review of many marketed SARM products, only about half of the vendors selling the “SARMs” were actually doing so with accurate labels.

Before taking any drug, you should speak to a doctor, especially if it’s a substance with limited safety data and unscheduled regulation.

How to Stack S4?

If you really want to use S4 but think the effects are underwhelming, you might consider using the substance with other SARMS as a stack.

For a bulking stack to put on lots of muscle, you will often use MK-2866 and GW-501516, both of these in small doses work wonderfully. Cardarine and Ostarine are great for improving strength but also bulking when in a caloric surplus. One should maintain a steady dosage of 20 mg for all three substances to avoid serious complications.

For a cutting stack, the best combination is offered by RAD-140 and Andarine. Testolone helps with serious strength gains, but Andarine helps with fat loss.  15 mg of each will help you lose weight fast without losing muscle or strength.

If you’re interested in SARMS for sale, ensure that you carefully assess the vendor and their reputation.

Fitness Content for You

Now that you know what Andarine is, how it works, and what it can/can’t do for you, you are that much closer to deciding if you would like to try it. In any case, with SARMs there’s no rush, it’s only better if you take your time.

Because of the unapproved and untried nature of SARMs, adequate research is necessary to mitigate the potential side effects and complications that might occur from use. If one is to begin taking any SARM without consideration for the side effects, one might experience long-term problems.

If you’re interested in learning more about the fitness industry or other health supplements, check out some of the recommended articles down below or on the sidebar.

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Abdul Aziz Mondal

Abdul Aziz Mondol is a professional blogger who is having a colossal interest in writing blogs and other jones of calligraphies. In terms of his professional commitments, he loves to share content related to business, finance, technology, and the gaming niche.

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